Repurposing lansoprazole to alleviate metabolic syndrome via PHOSPHO1 inhibition

• Main Authors: Yingting Wu (Author), Jiaqi Xin (Author), Xinyu Li (Author), Ting Yang (Author), Yi Liu (Author), Yongsheng Zhao (Author), Wen Xie (Author), Mengxi Jiang (Author)
• Format: Book
• Published: Elsevier, 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Drug repurposing offers an efficient approach to therapeutic development. In this study, our bioinformatic analysis first predicted an association between obesity and lansoprazole (LPZ), a commonly prescribed drug for gastrointestinal ulcers. We went on to show that LPZ treatment increased energy ex...