Canonical transient receptor potential channel 1 aggravates myocardial ischemia-and-reperfusion injury by upregulating reactive oxygen species

• Main Authors: Hui-Nan Zhang (Author), Meng Zhang (Author), Wen Tian (Author), Wei Quan (Author), Fan Song (Author), Shao-Yuan Liu (Author), Xiao-Xiao Liu (Author), Dan Mo (Author), Yang Sun (Author), Yuan-Yuan Gao (Author), Wen Ye (Author), Ying-Da Feng (Author), Chang-Yang Xing (Author), Chen Ye (Author), Lei Zhou (Author), Jing-Ru Meng (Author), Wei Cao (Author), Xiao-Qiang Li (Author)
• Format: Book
• Published: Elsevier, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The canonical transient receptor potential channel (TRPC) proteins form Ca2+-permeable cation channels that are involved in various heart diseases. However, the roles of specific TRPC proteins in myocardial ischemia/reperfusion (I/R) injury remain poorly understood. We observed that TRPC1 and TRPC6...