Identification of super-enhancer-driven peptidyl arginine deiminases as potential biomarkers and therapeutic targets for osimertinib-resistant non-small cell lung cancer

• Main Authors: Hang Li (Author), Gulizeba Muhetaer (Author), Yizi Xie (Author), Kainan Yao (Author), Qianqian Ma (Author), Huiting Guan (Author), Sizhong Xing (Author), Xiufang Huang (Author), Jihong Zhou (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Resistance to targeted drugs is now a challenging clinical problem in the treatment of non-small cell lung cancer (NSCLC). So far, there are no approved targeted therapeutic drugs for patients with disease progression after the third-generation epidermal growth factor receptor-tyrosine kinase inhibi...