Design, synthesis, and biological evaluation of novel iso-flavones derivatives as H3R antagonists

• Main Authors: Jian Xin (Author), Min Hu (Author), Qian Liu (Author), Tian Tai Zhang (Author), Dong Mei Wang (Author), Song Wu (Author)
• Format: Bog
• Udgivet: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Fag: article
• Online adgang: Connect to this object online.

Histamine H3 receptor (H3R), a kind of G-protein coupled receptor (GPCR), is expressed mainly in the central nervous system (CNS) and plays a vital role in homoeostatic control. This study describes the design and synthesis of a series of novel H3R antagonists based on the iso-flavone scaffold. The...