Design, synthesis, and biological evaluation of novel iso-flavones derivatives as H3R antagonists

• Váldodahkkit: Jian Xin (Dahkki), Min Hu (Dahkki), Qian Liu (Dahkki), Tian Tai Zhang (Dahkki), Dong Mei Wang (Dahkki), Song Wu (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Histamine H3 receptor (H3R), a kind of G-protein coupled receptor (GPCR), is expressed mainly in the central nervous system (CNS) and plays a vital role in homoeostatic control. This study describes the design and synthesis of a series of novel H3R antagonists based on the iso-flavone scaffold. The...