Targeting PDE4 as a promising therapeutic strategy in chronic ulcerative colitis through modulating mucosal homeostasis

• Main Authors: Heng Li (Author), Yao Zhang (Author), Moting Liu (Author), Chen Fan (Author), Chunlan Feng (Author), Qiukai Lu (Author), Caigui Xiang (Author), Huimin Lu (Author), Xiaoqian Yang (Author), Bing Wu (Author), Duowu Zou (Author), Wei Tang (Author)
• Format: Book
• Published: Elsevier, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Phosphodiesterase-4 (PDE4) functions as a catalyzing enzyme targeting hydrolyzation of intracellular cyclic adenosine monophosphate (cAMP) and inhibition of PDE4 has been proven to be a competitive strategy for dermatological and pulmonary inflammation. However, the pathological role of PDE4 and the...