Pharmacokinetics of Acetaminophen and Metformin Hydrochloride in Rats After Exposure to Simulated High Altitude Hypoxia

• Main Authors: Jun-bo Zhu (Author), Jian-xin Yang (Author), Yong-qiong Nian (Author), Gui-qin Liu (Author), Ya-bin Duan (Author), Xue Bai (Author), Qian Wang (Author), Yang Zhou (Author), Xue-jun Wang (Author), Ning Qu (Author), Xiang-yang Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The pharmacokinetic characteristics of drugs were altered under high altitude hypoxia, thereby affecting the absorption, distribution, metabolism, and excretion of drug. However, there are few literatures on the pharmacokinetic changes of antipyretic and pain-relieving drugs and cardiovascular syste...