Artemisinin analog SM934 alleviates epithelial barrier dysfunction via inhibiting apoptosis and caspase-1-mediated pyroptosis in experimental colitis

• Main Authors: Meijuan Shao (Author), Yuxi Yan (Author), Fenghua Zhu (Author), Xiaoqian Yang (Author), Qing Qi (Author), Fangming Yang (Author), Tingting Hao (Author), Zemin Lin (Author), Peilan He (Author), Yu Zhou (Author), Wei Tang (Author), Shijun He (Author), Jianping Zuo (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Intestinal barrier disruption due to the intestinal epithelial cells' (IECs) death is one of the critical pathological features of inflammatory bowel diseases (IBDs). SM934, an artemisinin analog, has previously been proven to ameliorate colitis induced by dextran sulfate sodium (DSS) in mice b...