Fluorescent in situ hybridization has limitations in screening NRG1 gene rearrangements

• Main Authors: Xiaomei Zhang (Author), Lin Li (Author), Fuping Gao (Author), Binbin Liu (Author), Jing Li (Author), Shuang Ren (Author), Shuangshuang Peng (Author), Wei Qiu (Author), Xiaohong Pu (Author), Qing Ye (Author)
• Format: Book
• Published: BMC, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background NRG1 fusion is a promising therapeutic target for various tumors but its prevalence is extremely low, and there are no standardized testing algorithms for genetic assessment. Mothods In this study, we analyzed 3008 tumors using Fluorescence in situ hybridization (FISH) and immuno...