Cover Image

Fluorescent in situ hybridization has limitations in screening NRG1 gene rearrangements

Abstract Background NRG1 fusion is a promising therapeutic target for various tumors but its prevalence is extremely low, and there are no standardized testing algorithms for genetic assessment. Mothods In this study, we analyzed 3008 tumors using Fluorescence in situ hybridization (FISH) and immuno...

Full description

Saved in:

Bibliographic Details
Main Authors:	Xiaomei Zhang (Author), Lin Li (Author), Fuping Gao (Author), Binbin Liu (Author), Jing Li (Author), Shuang Ren (Author), Shuangshuang Peng (Author), Wei Qiu (Author), Xiaohong Pu (Author), Qing Ye (Author)
Format:	Book
Published:	BMC, 2024-01-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Detection of ALK Gene Rearrangements in Non-Small Cell Lung Cancer by Immunocytochemistry and Fluorescence in Situ Hybridization on Cytologic Samples
by: Suneel RACHAGIRI, et al.
Published: (2022)

Inv dup del(10q): Identification by fluorescence in situ hybridization and array comparative genomic hybridization in a fetus with two concurrent chromosomal rearrangements
by: Chih-Ping Chen, et al.
Published: (2012)

Translational practice of fluorescence in situ hybridisation to identify neuroblastic tumours with TERT rearrangements
by: Yongbo Yu, et al.
Published: (2023)

In vitro fertilization outcomes after preimplantation genetic testing for chromosomal structural rearrangements comparing fluorescence in-situ hybridization, microarray comparative genomic hybridization, and next-generation sequencing
by: Chantal B. Bartels, M.D, et al.
Published: (2020)

HER 2 status in invasive breast cancer: Immunohistochemistry, fluorescence in-situ hybridization and chromogenic in-situ hybridization
by: Hemlata S Shirsat, et al.
Published: (2012)

Preimplantation genetic diagnosis by fluorescence in situ hybridization of reciprocal and Robertsonian translocations
by: Chun-Kai Chen, et al.
Published: (2014)

Differentiating and Categorizing of Liposarcoma and Synovial Sarcoma Neoplasms by Fluorescence in Situ Hybridization
by: Farhad Shahi, et al.
Published: (2017)

Detection of specific gene rearrangements by fluorescence in situ hybridization in 16 cases of clear cell sarcoma of soft tissue and 6 cases of clear cell sarcoma-like gastrointestinal tumor
by: Keiko Segawa, et al.
Published: (2018)

Interphase fluorescence in situ hybridization assisting in prenatal counseling for amniocentesis karyotyping-detected fetal mosaicism
by: Sheng-Yuan Su, et al.
Published: (2015)

Dual-color dual-hapten in situ hybridization (D-DISH) - Comparison with fluorescence in situ hybridization (FISH) for HER2/neu testing in breast cancer
by: Pooja K Gajaria, et al.
Published: (2020)

Application of fluorescent In situ hybridization for rapid detection of aggregatibacter actinomycetemcomitans in patients with chronic periodontitis
by: Kishore G Bhat, et al.
Published: (2018)

Fluorescence In Situ Hybridization (FISH) for the Characterization and Monitoring of Primary Cultures from Human Tumors
by: Ruth Román-Lladó, et al.
Published: (2023)

Fluorescence in situ hybridization patterns of BCR/ABL1 fusion in chronic myelogenous leukemia at diagnosis
by: Poonam P Jain, et al.
Published: (2012)

Pre-implantation genetic screening using fluorescence in situ hybridization in couples of Indian ethnicity: Is there a scope?
by: Shailaja Gada Saxena, et al.
Published: (2014)

Inv dup del(9p): Prenatal diagnosis and molecular cytogenetic characterization by fluorescence in situ hybridization and array comparative genomic hybridization
by: Chih-Ping Chen, et al.
Published: (2011)

CCND1 copy number increase and cyclin D1 expression in acral melanoma: a comparative study of fluorescence in situ hybridization and immunohistochemistry in a Chinese cohort
by: Jianying Liu, et al.
Published: (2021)

Comparison of Immunohistochemical and Fluorescence In Situ Hybridization Assessment for HER-2/neu Status in Taiwanese Breast Cancer Patients
by: Shou-Jen Kuo, et al.
Published: (2007)

Clear cell odontogenic carcinoma of jawbone diagnosed by fluorescence in situ testing in Ewing sarcoma RNA binding protein 1 gene rearrangements: A rare case report
by: Hung-Chi Huang, et al.
Published: (2023)

Fluorescence in situ hybridization (FISH) as an irreplaceable diagnostic tool for Williams-Beuren syndrome in developing countries: a literature review
by: Bianca Soares Carlotto, et al.
Published: (2023)

Clinical application of the HM-1000 image processing for HER2 fluorescence in situ hybridization signal quantification in breast cancer
by: Vicente Peg, et al.
Published: (2024)

Validation of break-apart and fusion MYC probes using a digital fluorescence in situ hybridization capture and imaging system
by: Michael Liew, et al.
Published: (2016)

Four-color fluorescence in-situ hybridization is useful to assist to distinguish early stage acral and cutaneous melanomas from dysplastic junctional or compound nevus
by: Yumei Lai, et al.
Published: (2020)

Rhodium Interaction with Human NRG1 Gene of Schizophrenia
by: Rukhsana Nawaz, et al.
Published: (2012)

NRG1 variant effects in patients with Hirschsprung disease
by: Gunadi, et al.
Published: (2018)

Detection of cytogenetic changes and chromosomal aneuploidy with fluorescent in situ hybridization in cytological specimens of oral cancers in Fanconi anemia-Proof of concept
by: Bruno Eduardo Silva de Araujo, et al.
Published: (2022)

Fluorescent in situ hybridization (FISH)-a quick screening tool for female children with palpable gonads for excluding androgen insensitivity syndrome
by: Mrinal Arora, et al.
Published: (2023)

Renal oncocytoma: a comparative clinicopathologic study and fluorescent in-situ hybridization analysis of 73 cases with long-term follow-up
by: Sherer Carol R, et al.
Published: (2010)

Correlation between HER2 gene amplification and protein overexpression through fluorescence in situ hybridization and immunohistochemistry in breast carcinoma patients
by: R N Makroo, et al.
Published: (2012)

Fluorescent in Situ Hybridization and Real-Time Quantitative Polymerase Chain Reaction to Evaluate HER-2/neu Status in Breast Cancer
by: Fatemeh Homaei Shandiz, et al.
Published: (2017)

Application of interphase fluorescence in situ hybridization to uncultured amniocytes for differential diagnosis of pseudomosaicism from true mosaicism in mosaic isochromosome 20q detected at amniocentesis
by: Chih-Ping Chen, et al.
Published: (2013)

Fluorescence in situ hybridization for diagnosis of malignant melanoma using RREB1, MYB, Cep6, and CCND1 probes in Japanese patients
by: Jun Aoi, et al.
Published: (2017)

The impact of NRG1 expressions and methylation on multifactorial Hirschsprung disease
by: Gunadi, et al.
Published: (2022)

Rapid positive confirmation of mosaicism for a small supernumerary marker chromosome as r(8) by interphase fluorescence in situ hybridization, quantitative fluorescent polymerase chain reaction, and array comparative genomic hybridization on uncultured amniocytes in a pregnancy with fetal pyelectasis
by: Chih-Ping Chen, et al.
Published: (2012)

Confirmation of a low HER2 positivity rate of breast carcinomas - limitations of immunohistochemistry and in situ hybridization
by: Vogel Ulrich F
Published: (2010)

Stratification of non-small cell lung cancer patients for therapy with epidermal growth factor receptor inhibitors: the EGFR fluorescence in situ hybridization assay
by: Varella-Garcia Marileila
Published: (2006)

Co-amplification and co-localization: Rare signal pattern in human epidermal growth factor receptor 2 gene fluorescence in situ hybridization testing
by: Anurag Gupta, et al.
Published: (2019)

Mosaic Ring Chromosome 18, Ring Chromosome 18 Duplication/Deletion and Disomy 18: Perinatal Findings and Molecular Cytogenetic Characterization by Fluorescence In Situ Hybridization and Array Comparative Genomic Hybridization
by: Chih-Ping Chen, et al.
Published: (2010)

Development of automated brightfield double <it>In Situ </it>hybridization (BDISH) application for <it>HER2 g</it>ene and chromosome 17 centromere (CEN 17) for breast carcinomas and an assay performance comparison to manual dual color <it>HER2 </it>fluorescence <it>In Situ </it>hybridization (FISH)
by: Wang Lin, et al.
Published: (2008)

Detection of no isochromosome 20q by interphase fluorescent in situ hybridization on uncultured amniocytes in a pregnancy with mosaic isochromosome 20q in cultured amniocytes at amniocentesis
by: Chih-Ping Chen, et al.
Published: (2015)

Interphase fluorescence in situ hybridization characterization of mosaicism using uncultured amniocytes and cultured stimulated cord blood lymphocytes in prenatally detected Pallister-Killian syndrome
by: Chih-Ping Chen, et al.
Published: (2014)