Arginine deprivation/citrulline augmentation with ADI-PEG20 as novel therapy for complications in type 2 diabetes

• Main Authors: Ammar A. Abdelrahman (Author), Porsche V. Sandow (Author), Jing Wang (Author), Zhimin Xu (Author), Modesto Rojas (Author), John S. Bomalaski (Author), Tahira Lemtalsi (Author), Ruth B. Caldwell (Author), Robert W. Caldwell (Author)
• Format: Book
• Published: Elsevier, 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Chronic inflammation and oxidative stress mediate the pathological progression of diabetic complications, like diabetic retinopathy (DR), peripheral neuropathy (DPN) and impaired wound healing. Studies have shown that treatment with a stable form of arginase 1 that reduces l-arginine leve...