Antimicrobial Properties and Mode of Action of Cryptdin-4, a Mouse α-Defensin Regulated by Peptide Redox Structures and Bacterial Cultivation Conditions

• Main Authors: Yi Wang (Author), Yuchi Song (Author), Shaonan Yan (Author), Rina Hiramine (Author), Yuki Ohnishi (Author), Yuki Yokoi (Author), Kiminori Nakamura (Author), Takashi Kikukawa (Author), Tokiyoshi Ayabe (Author), Tomoyasu Aizawa (Author)
• Format: Book
• Published: MDPI AG, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cryptdin-4 (crp4) is an enteric α-defensin derived from mice, and is a main mediator of immunity to oral infections and a determinant of the composition of the intestinal microbiota. Structurally, crp4 exists in two states: the oxidized form (crp4oxi), constrained by three invariant disulfide bonds,...