The chaperone domain BRICHOS prevents CNS toxicity of amyloid-β peptide in Drosophila melanogaster

• Main Authors: Erik Hermansson (Author), Sebastian Schultz (Author), Damian Crowther (Author), Sara Linse (Author), Bengt Winblad (Author), Gunilla Westermark (Author), Jan Johansson (Author), Jenny Presto (Author)
• Format: Book
• Published: The Company of Biologists, 2014-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aggregation of the amyloid-β peptide (Aβ) into toxic oligomers and amyloid fibrils is linked to the development of Alzheimer's disease (AD). Mutations of the BRICHOS chaperone domain are associated with amyloid disease and recent in vitro data show that BRICHOS efficiently delays Aβ42 oligomeri...