New pyrazolylpyrazoline derivatives as dual acting antimalarial-antileishamanial agents: synthesis, biological evaluation and molecular modelling simulations

• Main Authors: Adnan A. Bekhit (Author), Eskedar T. Lodebo (Author), Ariaya Hymete (Author), Hanan M. Ragab (Author), Salma A. Bekhit (Author), Kikuko Amagase (Author), Afnan Batubara (Author), Mohammed A. S. Abourehab (Author), Alaa El-Din A. Bekhit (Author), Tamer M. Ibrahim (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Promising inhibitory activities of the parasite multiplication were obtained upon evaluation of in vivo antimalarial activities of new pyrazolylpyrazoline derivatives against Plasmodium berghei infected mice. Further evaluation of 5b and 6a against chloroquine-resistant strain (RKL9) of P. falciparu...