Silymarin Activates c-AMP Phosphodiesterase and Stimulates Insulin Secretion in a Glucose-Dependent Manner in HIT-T15 Cells

• Main Authors: Ran Meng (Author), Jana Mahadevan (Author), Elizabeth Oseid (Author), Sara Vallerie (Author), R. Paul Robertson (Author)
• Formato: Livro
• Publicado em: MDPI AG, 2016-12-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Silymarin (SIL) is a flavonoid extracted from milk thistle seed that has been reported to decrease hyperglycemia in people with type 2 diabetes (T2D). However, it is not known whether SIL has direct secretory effects on β-cells. Using the β-cell line HIT-T15, SIL was shown to decrease intracellular...