Busulfan systemic exposure and its relationship with efficacy and safety in hematopoietic stem cell transplantation in children: a meta-analysis

• Hoofdauteurs: Xinying Feng (Auteur), Yunjiao Wu (Auteur), Jingru Zhang (Auteur), Jiapeng Li (Auteur), Guanghua Zhu (Auteur), Duanfang Fan (Auteur), Changqing Yang (Auteur), Libo Zhao (Auteur)
• Formaat: Boek
• Gepubliceerd in: BMC, 2020-04-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Abstract Background Busulfan (Bu) is a key component of several conditioning regimens used before hematopoietic stem cell transplantation (HSCT). However, the optimum systemic exposure (expressed as the area under the concentration-time curve [AUC]) of Bu for clinical outcome in children is controve...