Busulfan systemic exposure and its relationship with efficacy and safety in hematopoietic stem cell transplantation in children: a meta-analysis

• Main Authors: Xinying Feng (Author), Yunjiao Wu (Author), Jingru Zhang (Author), Jiapeng Li (Author), Guanghua Zhu (Author), Duanfang Fan (Author), Changqing Yang (Author), Libo Zhao (Author)
• Format: Book
• Published: BMC, 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Busulfan (Bu) is a key component of several conditioning regimens used before hematopoietic stem cell transplantation (HSCT). However, the optimum systemic exposure (expressed as the area under the concentration-time curve [AUC]) of Bu for clinical outcome in children is controve...