NQO1 protects against clioquinol toxicity

• Main Authors: Jamuna Chhetri (Author), Jem Dilek (Author), Noel Davies (Author), Glenn Jacobson (Author), Robert Dallmann (Author), Nuri Gueven (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Clioquinol (CQ) was widely used as oral antibiotic before being taken off the market in many countries in 1970, after it was linked to subacute myelo-optic neuropathy (SMON) in Japan, leading to vision loss with many patients left wheelchair-bound. The common pathology of CQ-associated SMON was repr...