From Synthetic Fragments of Endogenous Three-Finger Proteins to Potential Drugs

• Main Authors: Elena V. Kryukova (Author), Natalia S. Egorova (Author), Denis S. Kudryavtsev (Author), Dmitry S. Lebedev (Author), Ekaterina N. Spirova (Author), Maxim N. Zhmak (Author), Aleksandra I. Garifulina (Author), Igor E. Kasheverov (Author), Yuri N. Utkin (Author), Victor I. Tsetlin (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The proteins of the Ly6 family have a three-finger folding as snake venom α-neurotoxins, targeting nicotinic acetylcholine receptors (nAChRs), and some of them, like mammalian secreted Ly6/uPAR protein (SLURP1) and membrane-attached Ly-6/neurotoxin (Lynx1), also interact with distinct nAChR subtypes...