A linked physiologically based pharmacokinetic model for hydroxychloroquine and metabolite desethylhydroxychloroquine in SARS‐CoV‐2(−)/(+) populations

• Asıl Yazarlar: Claire Steinbronn (Yazar), Yashpal S. Chhonker (Yazar), Jenell Stewart (Yazar), Hannah Leingang (Yazar), Kate B. Heller (Yazar), Meighan L. Krows (Yazar), Michael Paasche‐Orlow (Yazar), Anna Bershteyn (Yazar), Helen C. Stankiewicz Karita (Yazar), Vaidehi Agrawal (Yazar), Miriam Laufer (Yazar), Raphael Landovitz (Yazar), Mark Wener (Yazar), Daryl J. Murry (Yazar), Christine Johnston (Yazar), Ruanne V. Barnabas (Yazar), Samuel L. M. Arnold (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Wiley, 2023-07-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Abstract Hydroxychloroquine (HCQ) is Food and Drug Administration (FDA)‐approved for malaria, systemic and chronic discoid lupus erythematosus, and rheumatoid arthritis. Because HCQ has a proposed multimodal mechanism of action and a well‐established safety profile, it is often investigated as a rep...