A linked physiologically based pharmacokinetic model for hydroxychloroquine and metabolite desethylhydroxychloroquine in SARS‐CoV‐2(−)/(+) populations

• Main Authors: Claire Steinbronn (Author), Yashpal S. Chhonker (Author), Jenell Stewart (Author), Hannah Leingang (Author), Kate B. Heller (Author), Meighan L. Krows (Author), Michael Paasche‐Orlow (Author), Anna Bershteyn (Author), Helen C. Stankiewicz Karita (Author), Vaidehi Agrawal (Author), Miriam Laufer (Author), Raphael Landovitz (Author), Mark Wener (Author), Daryl J. Murry (Author), Christine Johnston (Author), Ruanne V. Barnabas (Author), Samuel L. M. Arnold (Author)
• Format: Book
• Published: Wiley, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Hydroxychloroquine (HCQ) is Food and Drug Administration (FDA)‐approved for malaria, systemic and chronic discoid lupus erythematosus, and rheumatoid arthritis. Because HCQ has a proposed multimodal mechanism of action and a well‐established safety profile, it is often investigated as a rep...