Mitragyna speciosa leaf extract exhibits antipsychotic-like effect with the potential to alleviate positive and negative symptoms of psychosis in mice

• Main Authors: Kamini Vijeepallam (Author), Vijayapandi Pandy (Author), Thubasni Kunasegaran (Author), Dharmani Devi Murugan (Author), Murali Naidu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2016-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this study, we investigated the antipsychotic-like effect of methanolic extract of Mitragyna speciosa leaf (MMS) using in vivo and ex vivo studies. In vivo studies comprised of apomorphine-induced climbing behaviour, haloperidol-induced catalepsy, and ketamine-induced social withdrawal tests in m...