MicroRNA-19a-PTEN Axis Is Involved in the Developmental Decline of Axon Regenerative Capacity in Retinal Ganglion Cells

• Main Authors: Heather K. Mak (Author), Jasmine S.Y. Yung (Author), Robert N. Weinreb (Author), Shuk Han Ng (Author), Xu Cao (Author), Tracy Y.C. Ho (Author), Tsz Kin Ng (Author), Wai Kit Chu (Author), Wing Ho Yung (Author), Kwong Wai Choy (Author), Chi Chiu Wang (Author), Tin Lap Lee (Author), Christopher Kai-shun Leung (Author)
• Format: Book
• Published: Elsevier, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Irreversible blindness from glaucoma and optic neuropathies is attributed to retinal ganglion cells (RGCs) losing the ability to regenerate axons. While several transcription factors and proteins have demonstrated enhancement of axon regeneration after optic nerve injury, mechanisms contributing to...