Carcinoma-associated fibroblast-derived lysyl oxidase-rich extracellular vesicles mediate collagen crosslinking and promote epithelial-mesenchymal transition via p-FAK/p-paxillin/YAP signaling

• Main Authors: Xue Liu (Author), Jiao Li (Author), Xuesong Yang (Author), Xiaojie Li (Author), Jing Kong (Author), Dongyuan Qi (Author), Fuyin Zhang (Author), Bo Sun (Author), Yuehua Liu (Author), Tingjiao Liu (Author)
• Format: Book
• Published: Nature Publishing Group, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Carcinoma-associated fibroblasts (CAFs) are the main cellular components of the tumor microenvironment and promote cancer progression by modifying the extracellular matrix (ECM). The tumor-associated ECM is characterized by collagen crosslinking catalyzed by lysyl oxidase (LOX). Small extra...