Carcinoma-associated fibroblast-derived lysyl oxidase-rich extracellular vesicles mediate collagen crosslinking and promote epithelial-mesenchymal transition via p-FAK/p-paxillin/YAP signaling

• Egile Nagusiak: Xue Liu (Egilea), Jiao Li (Egilea), Xuesong Yang (Egilea), Xiaojie Li (Egilea), Jing Kong (Egilea), Dongyuan Qi (Egilea), Fuyin Zhang (Egilea), Bo Sun (Egilea), Yuehua Liu (Egilea), Tingjiao Liu (Egilea)
• Formatua: Liburua
• Argitaratua: Nature Publishing Group, 2023-08-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Abstract Carcinoma-associated fibroblasts (CAFs) are the main cellular components of the tumor microenvironment and promote cancer progression by modifying the extracellular matrix (ECM). The tumor-associated ECM is characterized by collagen crosslinking catalyzed by lysyl oxidase (LOX). Small extra...