Activation of innate immunity during development induces unresolved dysbiotic inflammatory gut and shortens lifespan

• Hlavní autoři: Kyoko Yamashita (Autor), Ayano Oi (Autor), Hina Kosakamoto (Autor), Toshitaka Yamauchi (Autor), Hibiki Kadoguchi (Autor), Takayuki Kuraishi (Autor), Masayuki Miura (Autor), Fumiaki Obata (Autor)
• Médium: Kniha
• Vydáno: The Company of Biologists, 2021-09-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

An early-life inflammatory response is associated with risks of age-related pathologies. How transient immune signalling activity during animal development influences life-long fitness is not well understood. Using Drosophila as a model, we find that activation of innate immune pathway Immune defici...