Activation of innate immunity during development induces unresolved dysbiotic inflammatory gut and shortens lifespan

• Main Authors: Kyoko Yamashita (Author), Ayano Oi (Author), Hina Kosakamoto (Author), Toshitaka Yamauchi (Author), Hibiki Kadoguchi (Author), Takayuki Kuraishi (Author), Masayuki Miura (Author), Fumiaki Obata (Author)
• Format: Book
• Published: The Company of Biologists, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

An early-life inflammatory response is associated with risks of age-related pathologies. How transient immune signalling activity during animal development influences life-long fitness is not well understood. Using Drosophila as a model, we find that activation of innate immune pathway Immune defici...