Effect of active oxygen gel on the clinical parameters of MRONJ

• Asıl Yazarlar: Bruna Cristina de Cristo (Yazar), Hassan Yousef Saleh (Yazar), Suyany Weiss (Yazar), Aline Sebastiani (Yazar), Mohammed Elsalanty (Yazar), Rafaela Scariot (Yazar), Tatiana Miranda Deliberador (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Elsevier, 2024-11-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Özet

Purpose: The aim of this work was to evaluate the effectiveness of a gel with active oxygen in the prevention of MRONJ. Methods: Using split-mouth study design, twelve Wistar rats were used, females (n = 6) and males (n = 6). All rats received a weekly intravenous injection of zoledronate (80 μg / kg body weight in PBS) for 8 weeks. Then, the animals underwent surgery to remove the first and second right and left mandibular molars to induce osteonecrosis. The animals received topical application of oxygen gel (blue®m) on the right-side extraction site (Group T) 3 times a week until euthanasia after 6 weeks, with no intervention on the left side (Group C). The clinical parameters analyzed included the presence and dimension of bone exposure, suppuration and epithelialization. Results: Statistical analysis using chi-square and Mann-Whitney test (p value < 0.05) demonstrated that group C had more severe signs of MRONJ at euthanasia than in the group T. Conclusion: Within the limitations of this pilot study, we can conclude that the application of active oxygen gel could be beneficial in the prevention of MRONJ.

Diğer Bilgileri

1013-9052
10.1016/j.sdentj.2024.09.003