Doxorubicin-Loaded Lipid Nanoparticles Coated with Calcium Phosphate as a Potential Tool in Human and Canine Osteosarcoma Therapy

• Main Authors: Daniela Chirio (Author), Simona Sapino (Author), Giulia Chindamo (Author), Elena Peira (Author), Cristina Vercelli (Author), Chiara Riganti (Author), Maela Manzoli (Author), Graziana Gambino (Author), Giovanni Re (Author), Marina Gallarate (Author)
• Format: Book
• Published: MDPI AG, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Osteosarcoma (OSA) is the most frequently diagnosed primary malignant bone tumor in humans and dogs. In both species, standard chemotherapy can be limited by multidrug resistance of neoplastic cells, which prevents intracellular accumulation of cytotoxic drugs, resulting in chemotherapy failure. In...