Alterations in nuclear structure promote lupus autoimmunity in a mouse model

• Autori principali: Namrata Singh (Autore), Duncan B. Johnstone (Autore), Kayla A. Martin (Autore), Italo Tempera (Autore), Mariana J. Kaplan (Autore), Michael F. Denny (Autore)
• Natura: Libro
• Pubblicazione: The Company of Biologists, 2016-08-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by the development of autoantibodies that recognize components of the cell nucleus. The vast majority of lupus research has focused on either the contributions of immune cell dysfunction or the genetics of the disease. Becaus...