Trichostatin A destabilizes HIF-2α through a VHL-independent but proteasome-dependent pathway in cancer cell lines and tumor xenografts

• Główni autorzy: Qingcheng Yang (Autor), Yuzhen Du (Autor), Dongdong Cheng (Autor), Zhichang Zhang (Autor), Xinhui Du (Autor)
• Format: Książka
• Wydane: Bangladesh Pharmacological Society, 2013-03-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Histone deacetylase (HDACs) inhibitors are a new generation of anti-cancer agents. Little is known regarding the effect of HDAC inhibitors on HIF-2α. The effect of trichostatin A (TSA), a class I/II HDAC inhibitor, on HIF-2α protein expression was investiagted in cancer cell lines and tumor xenograf...