Trichostatin A destabilizes HIF-2α through a VHL-independent but proteasome-dependent pathway in cancer cell lines and tumor xenografts

• 主要な著者: Qingcheng Yang (著者), Yuzhen Du (著者), Dongdong Cheng (著者), Zhichang Zhang (著者), Xinhui Du (著者)
• フォーマット: 図書
• 出版事項: Bangladesh Pharmacological Society, 2013-03-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Histone deacetylase (HDACs) inhibitors are a new generation of anti-cancer agents. Little is known regarding the effect of HDAC inhibitors on HIF-2α. The effect of trichostatin A (TSA), a class I/II HDAC inhibitor, on HIF-2α protein expression was investiagted in cancer cell lines and tumor xenograf...