Trichostatin A destabilizes HIF-2α through a VHL-independent but proteasome-dependent pathway in cancer cell lines and tumor xenografts

Histone deacetylase (HDACs) inhibitors are a new generation of anti-cancer agents. Little is known regarding the effect of HDAC inhibitors on HIF-2α. The effect of trichostatin A (TSA), a class I/II HDAC inhibitor, on HIF-2α protein expression was investiagted in cancer cell lines and tumor xenograf...

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Main Authors: Qingcheng Yang (Author), Yuzhen Du (Author), Dongdong Cheng (Author), Zhichang Zhang (Author), Xinhui Du (Author)
Format: Book
Published: Bangladesh Pharmacological Society, 2013-03-01T00:00:00Z.
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