Unveiling acquired resistance to anti-EGFR therapies in colorectal cancer: a long and winding road

• Main Authors: Alejandro Ríos-Hoyo (Author), Xavier Monzonís (Author), Joana Vidal (Author), Jenniffer Linares (Author), Clara Montagut (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Emergence of acquired resistance limits the efficacy of the anti-EGFR therapies cetuximab and panitumumab in metastatic colorectal cancer. In the last decade, preclinical and clinical cohort studies have uncovered genomic alterations that confer a selective advantage to tumor cells under EGFR blocka...