Prognostic role of copeptin with all-cause mortality after heart failure: a systematic review and meta-analysis
Peng Zhang, Xiaomei Wu, Guangxiao Li, Hao Sun, Jingpu Shi Department of Clinical Epidemiology, Center of Evidence-Based Medicine, Institute of Cardiovascular Disease, The First Hospital of China Medical University, Shenyang, People’s Republic of China Background: As the C-terminal section...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Book |
| Published: |
Dove Medical Press,
2017-01-01T00:00:00Z.
|
| Subjects: | |
| Online Access: | Connect to this object online. |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
MARC
| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_c295ae90c4d24cea9ab745ed1df16a68 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Zhang P |e author |
| 700 | 1 | 0 | |a Wu X |e author |
| 700 | 1 | 0 | |a Li G |e author |
| 700 | 1 | 0 | |a Sun H |e author |
| 700 | 1 | 0 | |a Shi J |e author |
| 245 | 0 | 0 | |a Prognostic role of copeptin with all-cause mortality after heart failure: a systematic review and meta-analysis |
| 260 | |b Dove Medical Press, |c 2017-01-01T00:00:00Z. | ||
| 500 | |a 1178-203X | ||
| 520 | |a Peng Zhang, Xiaomei Wu, Guangxiao Li, Hao Sun, Jingpu Shi Department of Clinical Epidemiology, Center of Evidence-Based Medicine, Institute of Cardiovascular Disease, The First Hospital of China Medical University, Shenyang, People’s Republic of China Background: As the C-terminal section of vasopressin precursor, copeptin has been recently suggested as a new prognostic biomarker after heart failure (HF). Thus, the aim of this study was to evaluate the prognostic value of plasma copeptin level with all-cause mortality in patients with HF.Methods: Comprehensive strategies were used to search relevant studies from electronic databases. Pooled hazard ratios (HRs) and standardized mean differences (SMDs) together with their 95% confidence intervals (CIs) were calculated. Subgroup analysis and sensitivity analysis were performed to find the potential sources of heterogeneity.Results: A total of 5,989 participants from 17 prospective studies were included in this meta-analysis. A significant association was observed between circulating copeptin levels and risk of all-cause mortality in patients with HF (categorical copeptin: HR =1.69, 95% CI =1.42–2.01; per unit copeptin: HR =1.03, 95% CI =1.00–1.07; log unit copeptin: HR =3.26, 95% CI =0.95–11.25). Pooled SMD showed that copeptin levels were significantly higher in patients with HF who died during the follow-up period than in survivors (SMD =1.19, 95% CI =0.81–1.57). Subgroup analyses also confirmed this significant association, while sensitivity analyses indicated that the overall results were stable.Conclusion: This study demonstrated that circulating copeptin seemed to be a novel biomarker to provide better prediction of all-cause mortality in patients with HF. Keywords: heart failure, copeptin, all-cause mortality, meta-analysis | ||
| 546 | |a EN | ||
| 690 | |a Heart failure (HF) | ||
| 690 | |a copeptin | ||
| 690 | |a all-cause mortality | ||
| 690 | |a meta-analysis | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Therapeutics and Clinical Risk Management, Vol Volume 13, Pp 49-58 (2017) | |
| 787 | 0 | |n https://www.dovepress.com/prognostic-role-of-copeptin-with-all-cause-mortality-after-heart-failu-peer-reviewed-article-TCRM | |
| 787 | 0 | |n https://doaj.org/toc/1178-203X | |
| 856 | 4 | 1 | |u https://doaj.org/article/c295ae90c4d24cea9ab745ed1df16a68 |z Connect to this object online. |