Exploring structure-activity relationship of S-substituted 2-mercaptoquinazolin-4(3H)-one including 4-ethylbenzenesulfonamides as human carbonic anhydrase inhibitors

Inhibitory action of newly synthesised 4-(2-(2-substituted-thio-4-oxoquinazolin-3(4H)-yl)ethyl)benzenesulfonamides compounds 2-13 against human carbonic anhydrase (CA, EC 4.2.1.1) (hCA) isoforms I, II, IX, and XII, was evaluated. hCA I was efficiently inhibited by compounds 2-13 with inhibition cons...

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Main Authors: Adel S. El-Azab (Author), Alaa A.-M (Author), Hany E. A. Ahmed (Author), Sivia Bua (Author), Alessio Nocentini (Author), Nawaf A. AlSaif (Author), Ahmad J. Obaidullah (Author), Mohamed M. Hefnawy (Author), Claudiu T. Supuran (Author)
Format: Book
Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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