Ensemble of structure and ligand-based classification models for hERG liability profiling

• Main Authors: Serena Vittorio (Author), Filippo Lunghini (Author), Alessandro Pedretti (Author), Giulio Vistoli (Author), Andrea R. Beccari (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Drug-induced cardiotoxicity represents one of the most critical safety concerns in the early stages of drug development. The blockade of the human ether-à-go-go-related potassium channel (hERG) is the most frequent cause of cardiotoxicity, as it is associated to long QT syndrome which can lead to fa...