Novel Ex Vivo Culture Method for the Study of Dupuytren's Disease: Effects of TGFβ Type 1 Receptor Modulation by Antisense Oligonucleotides

• Main Authors: Sofia Karkampouna (Author), Boudewijn PT Kruithof (Author), Peter Kloen (Author), Miryam C Obdeijn (Author), Annelies MA van der Laan (Author), Hans J Tanke (Author), Dwi U Kemaladewi (Author), Willem MH Hoogaars (Author), Peter AC 't Hoen (Author), Annemieke Aartsma-Rus (Author), Ian M Clark (Author), Peter ten Dijke (Author), Marie-José Goumans (Author), Marianna Kruithof-de Julio (Author)
• Format: Book
• Published: Elsevier, 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dupuytren's disease (DD) is a benign fibroproliferative disease of the hand. It is characterized by the excessive production of extracellular matrix (ECM) proteins, which form a strong fibrous tissue between the handpalm and fingers, permanently disrupting the fine movement ability. The major c...