Dosimetry of [18F]TRACK, the first PET tracer for imaging of TrkB/C receptors in humans

• Main Authors: Alexander Thiel (Author), Alexey Kostikov (Author), Hailey Ahn (Author), Youstina Daoud (Author), Jean-Paul Soucy (Author), Stephan Blinder (Author), Carolin Jaworski (Author), Carmen Wängler (Author), Björn Wängler (Author), Freimut Juengling (Author), Shirin A. Enger (Author), Ralf Schirrmacher (Author)
• Format: Book
• Published: SpringerOpen, 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Reduced expression or impaired signalling of tropomyosin receptor kinases (Trk receptors) are found in a vast spectrum of CNS disorders. [18F]TRACK is the first PET radioligand for TrkB/C with proven in vivo brain penetration and on-target specific signal. Here we report dosimetr...