Tetrahedral DNA nanostructures synergize with MnO2 to enhance antitumor immunity via promoting STING activation and M1 polarization

• Main Authors: Siping Liang (Author), Jiaying Li (Author), Zhengyu Zou (Author), Miao Mao (Author), Siqi Ming (Author), Fan Lin (Author), Ziyan Zhang (Author), Can Cao (Author), Jinyu Zhou (Author), Yuanqing Zhang (Author), Jiaping Li (Author), Minhao Wu (Author)
• Format: Book
• Published: Elsevier, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Stimulator of interferon genes (STING) is a cytosolic DNA sensor which is regarded as a potential target for antitumor immunotherapy. However, clinical trials of STING agonists display limited anti-tumor effects and dose-dependent side-effects like inflammatory damage and cell toxicity. Here, we sho...