Are body surface area based estimates of liver volume applicable to children with overweight or obesity? An in vivo validation study

• Main Authors: Chelsea Hosey‐Cojocari (Author), Sherwin S. Chan (Author), Chance S. Friesen (Author), Amie Robinson (Author), Veronica Williams (Author), Erica Swanson (Author), Daniel O'Toole (Author), Jansynn Radford (Author), Neil Mardis (Author), Trevor N. Johnson (Author), J. Steven Leeder (Author), Valentina Shakhnovich (Author)
• Format: Book
• Published: Wiley, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The liver is the primary organ responsible for clearing most drugs from the body and thus determines systemic drug concentrations over time. Drug clearance by the liver appears to be directly related to organ size. In children, organ size changes as children age and grow. Liver volume has b...