Are body surface area based estimates of liver volume applicable to children with overweight or obesity? An in vivo validation study

• Главные авторы: Chelsea Hosey‐Cojocari (Автор), Sherwin S. Chan (Автор), Chance S. Friesen (Автор), Amie Robinson (Автор), Veronica Williams (Автор), Erica Swanson (Автор), Daniel O'Toole (Автор), Jansynn Radford (Автор), Neil Mardis (Автор), Trevor N. Johnson (Автор), J. Steven Leeder (Автор), Valentina Shakhnovich (Автор)
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• Опубликовано: Wiley, 2021-09-01T00:00:00Z.
• Предметы: article
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Abstract The liver is the primary organ responsible for clearing most drugs from the body and thus determines systemic drug concentrations over time. Drug clearance by the liver appears to be directly related to organ size. In children, organ size changes as children age and grow. Liver volume has b...