Up-regulation of ABCG1 is associated with methotrexate resistance in acute lymphoblastic leukemia cells

• Main Authors: Yao Chen (Author), Houshun Fang (Author), Huiying Sun (Author), Xiaoyu Wu (Author), Yan Xu (Author), Bin-Bing S. Zhou (Author), Hui Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Acute lymphoblastic leukemia (ALL) is a prevalent hematologic malignancy in children, and methotrexate (MTX) is a widely employed curative treatment. Despite its common use, clinical resistance to MTX is frequently encountered. In this study, an MTX-resistant cell line (Reh-MTXR) was established thr...