Up-regulation of ABCG1 is associated with methotrexate resistance in acute lymphoblastic leukemia cells

• Hlavní autoři: Yao Chen (Autor), Houshun Fang (Autor), Huiying Sun (Autor), Xiaoyu Wu (Autor), Yan Xu (Autor), Bin-Bing S. Zhou (Autor), Hui Li (Autor)
• Médium: Kniha
• Vydáno: Frontiers Media S.A., 2024-01-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

Acute lymphoblastic leukemia (ALL) is a prevalent hematologic malignancy in children, and methotrexate (MTX) is a widely employed curative treatment. Despite its common use, clinical resistance to MTX is frequently encountered. In this study, an MTX-resistant cell line (Reh-MTXR) was established thr...