An Interspecies Molecular and Functional Study of Organic Cation Transporters at the Blood-Brain Barrier: From Rodents to Humans

• Main Authors: Catarina Chaves (Author), Federica Campanelli (Author), Hélène Chapy (Author), David Gomez-Zepeda (Author), Fabienne Glacial (Author), Maria Smirnova (Author), Meryam Taghi (Author), Johan Pallud (Author), Nicolas Perrière (Author), Xavier Declèves (Author), Marie-Claude Menet (Author), Salvatore Cisternino (Author)
• Format: Book
• Published: MDPI AG, 2020-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Organic cation transporters (OCTs) participate in the handling of compounds in kidneys and at the synaptic cleft. Their role at the blood-brain barrier (BBB) in brain drug delivery is still unclear. The presence of OCT1,2,3 (SLC22A1-3) in mouse, rat and human isolated brain microvessels was investig...