An Interspecies Molecular and Functional Study of Organic Cation Transporters at the Blood-Brain Barrier: From Rodents to Humans

• Автори: Catarina Chaves (Автор), Federica Campanelli (Автор), Hélène Chapy (Автор), David Gomez-Zepeda (Автор), Fabienne Glacial (Автор), Maria Smirnova (Автор), Meryam Taghi (Автор), Johan Pallud (Автор), Nicolas Perrière (Автор), Xavier Declèves (Автор), Marie-Claude Menet (Автор), Salvatore Cisternino (Автор)
• Формат: Книга
• Опубліковано: MDPI AG, 2020-03-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Organic cation transporters (OCTs) participate in the handling of compounds in kidneys and at the synaptic cleft. Their role at the blood-brain barrier (BBB) in brain drug delivery is still unclear. The presence of OCT1,2,3 (SLC22A1-3) in mouse, rat and human isolated brain microvessels was investig...