Computer-assisted imaging algorithms facilitate histomorphometric quantification of kidney damage in rodent renal failure models

• Main Authors: Marcin Klapczynski (Author), Gerard D Gagne (Author), Sherry J Morgan (Author), Kelly J Larson (Author), Bruce E LeRoy (Author), Eric A Blomme (Author), Bryan F Cox (Author), Eugene W Shek (Author)
• Format: Book
• Published: Elsevier, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Surgical 5/6 nephrectomy and adenine-induced kidney failure in rats are frequently used models of progressive renal failure. In both models, rats develop significant morphological changes in the kidneys and quantification of these changes can be used to measure the efficacy of prophyla...