Nanoalbumin-prodrug conjugates prepared via a thiolation‐and‐conjugation method improve cancer chemotherapy and immune checkpoint blockade therapy by promoting CD8+ T‐cell infiltration

• Main Authors: Long Chen (Author), Nuo Xu (Author), Pan Wang (Author), Haichuan Zhu (Author), Zijian Zhang (Author), Zhanqun Yang (Author), Wenyuan Zhang (Author), Hongyan Guo (Author), Jian Lin (Author)
• Format: Book
• Published: Wiley, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Protein-drug conjugates are emerging tools to combat cancers. Here, we adopted an indirect thiolation‐and‐conjugation method as a general strategy to prepare protein-drug conjugates. We found for the first time that this method led to the formation of nanometric conjugates, probably due to...