Development of Lyophilized Gemini Surfactant-Based Gene Delivery Systems: Influence of Lyophilization on the Structure, Activity and Stability of the Lipoplexes

• Main Authors: Waleed Mohammed-Saeid (Author), Deborah Michel (Author), Anas El-Aneed (Author), Ronald E Verrall (Author), Nicholas H Low (Author), Ildiko Badea (Author)
• Format: Book
• Published: Frontiers Media S.A., 2012-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose. Cationic gemini surfactants have been studied as non-viral vectors for gene therapy. Clinical applications of cationic lipid/DNA lipoplexes are restricted by their instability in aqueous formulations. In this work, we investigated the influence of lyophilization on the essential physiochemi...