Development of Lyophilized Gemini Surfactant-Based Gene Delivery Systems: Influence of Lyophilization on the Structure, Activity and Stability of the Lipoplexes

• Auteurs principaux: Waleed Mohammed-Saeid (Auteur), Deborah Michel (Auteur), Anas El-Aneed (Auteur), Ronald E Verrall (Auteur), Nicholas H Low (Auteur), Ildiko Badea (Auteur)
• Format: Livre
• Publié: Frontiers Media S.A., 2012-10-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Purpose. Cationic gemini surfactants have been studied as non-viral vectors for gene therapy. Clinical applications of cationic lipid/DNA lipoplexes are restricted by their instability in aqueous formulations. In this work, we investigated the influence of lyophilization on the essential physiochemi...