Anti-Osteoclast Effect of Exportin-1 Inhibitor Eltanexor on Osteoporosis Depends on Nuclear Accumulation of IκBα-NF-κB p65 Complex

• Main Authors: Junchun Chen (Author), Dezhi Song (Author), Yang Xu (Author), Liwei Wu (Author), Lili Tang (Author), YuanGang Su (Author), Xiaoxiao Xie (Author), Jinmin Zhao (Author), Jiake Xu (Author), Qian Liu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Osteoporosis affects around 200 million people globally, with menopausal women accounting for the bulk of cases. In the occurrence and development of osteoporosis, a key role is played by osteoclasts. Excessive osteoclast-mediated bone resorption activity reduces bone mass and increases bone fragili...