The Meckel-Gruber syndrome protein TMEM67 controls basal body positioning and epithelial branching morphogenesis in mice via the non-canonical Wnt pathway

• Main Authors: Zakia A. Abdelhamed (Author), Subaashini Natarajan (Author), Gabrielle Wheway (Author), Christopher F. Inglehearn (Author), Carmel Toomes (Author), Colin A. Johnson (Author), Daniel J. Jagger (Author)
• 格式: 图书
• 出版: The Company of Biologists, 2015-06-01T00:00:00Z.
• 主题: article
• 在线阅读: Connect to this object online.

Ciliopathies are a group of developmental disorders that manifest with multi-organ anomalies. Mutations in TMEM67 (MKS3) cause a range of human ciliopathies, including Meckel-Gruber and Joubert syndromes. In this study we describe multi-organ developmental abnormalities in the Tmem67tm1Dgen/H1 knock...