The Meckel-Gruber syndrome protein TMEM67 controls basal body positioning and epithelial branching morphogenesis in mice via the non-canonical Wnt pathway

The Meckel-Gruber syndrome protein TMEM67 controls basal body positioning and epithelial branching morphogenesis in mice via the non-canonical Wnt pathway

Ciliopathies are a group of developmental disorders that manifest with multi-organ anomalies. Mutations in TMEM67 (MKS3) cause a range of human ciliopathies, including Meckel-Gruber and Joubert syndromes. In this study we describe multi-organ developmental abnormalities in the Tmem67tm1Dgen/H1 knock...

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Main Authors: Zakia A. Abdelhamed (Author), Subaashini Natarajan (Author), Gabrielle Wheway (Author), Christopher F. Inglehearn (Author), Carmel Toomes (Author), Colin A. Johnson (Author), Daniel J. Jagger (Author)
Format: Book
Published: The Company of Biologists, 2015-06-01T00:00:00Z.
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