Differential Effects of Chronic Pulsatile versus Chronic Constant Maternal Hyperglycemia on Fetal Pancreatic β-Cells

• 主要な著者: Mackenzie S. Frost (著者), Aqib H. Zehri (著者), Sean W. Limesand (著者), William W. Hay (著者), Paul J. Rozance (著者)
• フォーマット: 図書
• 出版事項: Hindawi Limited, 2012-01-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Constant maternal hyperglycemia limits, while pulsatile maternal hyperglycemia may enhance, fetal glucose-stimulated insulin secretion (GSIS) in sheep. However, the impact of such different patterns of hyperglycemia on the development of the fetal β-cell is unknown. We measured the impact of one wee...