Photoreceptor degeneration in microphthalmia (Mitf) mice: partial rescue by pigment epithelium-derived factor

• Main Authors: Yu Chen (Author), Juan Yang (Author), Huiqin Geng (Author), Liping Li (Author), Jinyang Li (Author), Bing Cheng (Author), Xiaoyin Ma (Author), Huirong Li (Author), Ling Hou (Author)
• Format: Book
• Published: The Company of Biologists, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dysfunction and loss of the retinal pigment epithelium (RPE) are hallmarks of retinal degeneration, but the underlying pathogenetic processes are only partially understood. Using mice with a null mutation in the transcription factor gene Mitf, in which RPE deficiencies are associated with retinal de...