Oxidative stress and DNA lesions: the role of 8-oxoguanine lesions in Trypanosoma cruzi cell viability.

• Main Authors: Pedro H N Aguiar (Author), Carolina Furtado (Author), Bruno M Repolês (Author), Grazielle A Ribeiro (Author), Isabela C Mendes (Author), Eduardo F Peloso (Author), Fernanda R Gadelha (Author), Andrea M Macedo (Author), Glória R Franco (Author), Sérgio D J Pena (Author), Santuza M R Teixeira (Author), Leda Q Vieira (Author), Alessandra A Guarneri (Author), Luciana O Andrade (Author), Carlos R Machado (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The main consequence of oxidative stress is the formation of DNA lesions, which can result in genomic instability and lead to cell death. Guanine is the base that is most susceptible to oxidation, due to its low redox potential, and 8-oxoguanine (8-oxoG) is the most common lesion. These characterist...