Oxidative stress and DNA lesions: the role of 8-oxoguanine lesions in Trypanosoma cruzi cell viability.

• 主要な著者: Pedro H N Aguiar (著者), Carolina Furtado (著者), Bruno M Repolês (著者), Grazielle A Ribeiro (著者), Isabela C Mendes (著者), Eduardo F Peloso (著者), Fernanda R Gadelha (著者), Andrea M Macedo (著者), Glória R Franco (著者), Sérgio D J Pena (著者), Santuza M R Teixeira (著者), Leda Q Vieira (著者), Alessandra A Guarneri (著者), Luciana O Andrade (著者), Carlos R Machado (著者)
• フォーマット: 図書
• 出版事項: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

The main consequence of oxidative stress is the formation of DNA lesions, which can result in genomic instability and lead to cell death. Guanine is the base that is most susceptible to oxidation, due to its low redox potential, and 8-oxoguanine (8-oxoG) is the most common lesion. These characterist...