Safety and immunogenicity of the Na-GST-1 hookworm vaccine in Brazilian and American adults.

• Main Authors: David J Diemert (Author), Janaína Freire (Author), Vanderson Valente (Author), Carlos Geraldo Fraga (Author), Frederico Talles (Author), Shannon Grahek (Author), Doreen Campbell (Author), Amar Jariwala (Author), Maria Victoria Periago (Author), Martin Enk (Author), Maria Flávia Gazzinelli (Author), Maria Elena Bottazzi (Author), Robert Hamilton (Author), Jill Brelsford (Author), Anna Yakovleva (Author), Guangzhao Li (Author), Jin Peng (Author), Rodrigo Correa-Oliveira (Author), Peter Hotez (Author), Jeffrey Bethony (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Necator americanus Glutathione-S-Transferase-1 (Na-GST-1) plays a role in the digestion of host hemoglobin by adult N. americanus hookworms. Vaccination of laboratory animals with recombinant Na-GST-1 is associated with significant protection from challenge infection. Recombinant Na-GST-1 was expres...