Reconsidering anion inhibitors in the general context of drug design studies of modulators of activity of the classical enzyme carbonic anhydrase

• Główni autorzy: Alessio Nocentini (Autor), Andrea Angeli (Autor), Fabrizio Carta (Autor), Jean-Yves Winum (Autor), Raivis Zalubovskis (Autor), Simone Carradori (Autor), Clemente Capasso (Autor), William A. Donald (Autor), Claudiu T. Supuran (Autor)
• Format: Książka
• Wydane: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Inorganic anions inhibit the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1) generally by coordinating to the active site metal ion. Cyanate was reported as a non-coordinating CA inhibitor but those erroneous results were subsequently corrected by another group. We review the anion CA inhibitors (...