Nephroprotective effects of Datura stramonium leaves against methotrexate nephrotoxicity via attenuation of oxidative stress-mediated inflammation and apoptosis in rats

• Үндсэн зохиолчид: Esther Alum (Зохиогч), Ademola Famurewa (Зохиогч), Obasi Orji (Зохиогч), Patrick M Aja (Зохиогч), Felix Nwite (Зохиогч), Simon Ohuche (Зохиогч), Stanley Ukasoanya (Зохиогч), Lucy Nnaji (Зохиогч), Deborah Joshua (Зохиогч), Kingsley Igwe (Зохиогч), Stephen Chima (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Mashhad University of Medical Sciences, 2023-07-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

Objective: Methotrexate (MTX) is a frontline antimetabolite anticancer drug which is used in different cancer treatments but its nephrotoxicity is a notable drawback that limits its clinical use. The present study was undertaken to examine whether Datura stramonium leaf extract (DSLE) could block MT...