Nephroprotective effects of Datura stramonium leaves against methotrexate nephrotoxicity via attenuation of oxidative stress-mediated inflammation and apoptosis in rats

• Auteurs principaux: Esther Alum (Auteur), Ademola Famurewa (Auteur), Obasi Orji (Auteur), Patrick M Aja (Auteur), Felix Nwite (Auteur), Simon Ohuche (Auteur), Stanley Ukasoanya (Auteur), Lucy Nnaji (Auteur), Deborah Joshua (Auteur), Kingsley Igwe (Auteur), Stephen Chima (Auteur)
• Format: Livre
• Publié: Mashhad University of Medical Sciences, 2023-07-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Objective: Methotrexate (MTX) is a frontline antimetabolite anticancer drug which is used in different cancer treatments but its nephrotoxicity is a notable drawback that limits its clinical use. The present study was undertaken to examine whether Datura stramonium leaf extract (DSLE) could block MT...