Nephroprotective effects of Datura stramonium leaves against methotrexate nephrotoxicity via attenuation of oxidative stress-mediated inflammation and apoptosis in rats

• Main Authors: Esther Alum (Author), Ademola Famurewa (Author), Obasi Orji (Author), Patrick M Aja (Author), Felix Nwite (Author), Simon Ohuche (Author), Stanley Ukasoanya (Author), Lucy Nnaji (Author), Deborah Joshua (Author), Kingsley Igwe (Author), Stephen Chima (Author)
• Format: Book
• Published: Mashhad University of Medical Sciences, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Methotrexate (MTX) is a frontline antimetabolite anticancer drug which is used in different cancer treatments but its nephrotoxicity is a notable drawback that limits its clinical use. The present study was undertaken to examine whether Datura stramonium leaf extract (DSLE) could block MT...