Cannabimimetic <i>N</i>-Stearoylethanolamine as "Double-Edged Sword" in Anticancer Chemotherapy: Proapoptotic Effect on Tumor Cells and Suppression of Tumor Growth versus Its Bio-Protective Actions in Complex with Polymeric Carrier on General Toxicity of Doxorubicin In Vivo

• Main Authors: Rostyslav Panchuk (Author), Nadiya Skorokhyd (Author), Vira Chumak (Author), Lilya Lehka (Author), Halyna Kosiakova (Author), Tetyana Horid'ko (Author), Iehor Hudz (Author), Nadiya Hula (Author), Anna Riabtseva (Author), Nataliya Mitina (Author), Alexander Zaichenko (Author), Petra Heffeter (Author), Walter Berger (Author), Rostyslav Stoika (Author)
• Format: Book
• Published: MDPI AG, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study reports a dose-dependent pro-apoptotic action of synthetic cannabimimetic <i>N</i>-stearoylethanolamine (NSE) on diverse cancer cell lines, including multidrug-resistant models. No antioxidant or cytoprotective effects of NSE were found when it was applied together with doxoru...