Triple Combination of Ascorbate, Menadione and the Inhibition of Peroxiredoxin-1 Produces Synergistic Cytotoxic Effects in Triple-Negative Breast Cancer Cells

• Main Authors: Malgorzata Bajor (Author), Agnieszka Graczyk-Jarzynka (Author), Katsiaryna Marhelava (Author), Malgorzata Kurkowiak (Author), Arman Rahman (Author), Claudia Aura (Author), Niamh Russell (Author), Agata O. Zych (Author), Malgorzata Firczuk (Author), Magdalena Winiarska (Author), William M. Gallagher (Author), Radoslaw Zagozdzon (Author)
• Format: Book
• Published: MDPI AG, 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Triple-negative breast cancer (TNBC) is an aggressive form of mammary malignancy currently without satisfactory systemic treatment options. Agents generating reactive oxygen species (ROS), such as ascorbate (Asc) and menadione (Men), especially applied in combination, have been proposed as an altern...